The goal of this concept is to encourage research that aims to better understand the mechanisms and potential therapeutic impact of fast-acting psychotomimetic agents.
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Background
Large language models (LLMs) offer significant potential to streamline research workflows and enhance productivity. However, limited data exist on the extent of their adoption within the mental health research community.
ObjectiveWe examined how LLMs are being used in mental health...
Background
Differentiating major depressive disorder (MDD) from bipolar disorder (BD) remains a significant clinical challenge, as both disorders exhibit overlapping symptoms but require distinct treatment approaches. Advances in voxel-based morphometry and surface-based morphometry have facilitated the identification of structural brain...
Background
Depression is a major health issue in adolescence and young adulthood, emphasising the need for early risk identification. Patients with major depressive disorder (MDD) often show disturbed daily rest-activity patterns, but such changes are often confounded by medication intake,...
Background
Chronic inflammation is associated with psychiatric disorders. If inflammation is linked mechanistically to mental health, people living with chronic inflammatory conditions may experience mental health issues at higher rates than others.
ObjectiveTo test this hypothesis, we analysed data from 1...
Background
Approximately 30% of women experience intimate partner violence (IPV) in their lifetime, often with traumatic brain injury (TBI) exposure. Nevertheless, there has been limited research exploring lifelong brain health outcomes following IPV with TBI. To address this, we investigated...
Well-synchronised circadian rhythms are fundamental for human health and particularly mental health, but patterns of modern living—including, for example, shift work and excess light at night—can cause desynchronisation of rhythms and result in a wide range of adverse mental...
Background
The mental health of children and adolescents has declined in recent years. Self-harm is frequently an expression of this psychological distress.
ObjectivesTo examine trends in self-harm incidence among 10–24-year olds between January 2019–December 2023.
MethodsWe conducted time-series analyses of all incident...
Background
The onset of a severe physical illness of a child has been associated with earnings and employment losses among parents, but less is known in the context of children's mental disorders.
ObjectivesWe estimated parental income and employment trajectories associated with...
Background
Routine outcome data in secondary mental health services have significant potential for service planning, evaluation and research. Expanding the collection and use of these data is an ongoing priority in the National Health Service (NHS), but inconsistent use threatens...