Most low- and middle-income countries (LMICs) have poor or non-existent mental healthcare. Many of LMIC countries allocate less than 1% of their health budgets to addressing mental illness, making large-scale public health interventions not a practical option, at least...
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This editorial focuses on the seven studies published in the BMJ Mental Health topic collection Advances in Clinical Psychopharmacology in Children and Young People. Collectively, these articles provide evidence that informs key steps in the psychopharmacological management of children...
We argue that psychiatry has overlooked a significant modifiable risk factor for mental illness in female patients: cyclical symptoms associated with the menstrual cycle. Premenstrual dysphoric disorder has recently been included in the International Classification of Diseases-11, while there...
Background
Depression in older adults is often undertreated. A 2011 systematic review of treatments for treatment-resistant depression (TRD) in older adults identified one placebo-controlled randomised controlled trial (RCT). We aimed to update this review, synthesising evidence for the effectiveness of...
Objective
Agitation in the emergency department (ED) affects up to 2.6% of encounters, posing significant risks to patients and caregivers. This review investigates the impact of circadian rhythms on benzodiazepine (BZD) pharmacokinetics and pharmacodynamics, focusing on how dosing time influences...
Background
The subcallosal cingulate gyrus (SCG) is integral to cognitive function and mood regulation. Open-label SCG deep brain stimulation (DBS) studies demonstrate improvement or stabilisation of cognitive function in treatment-resistant depression (TRD).
ObjectiveThis randomised controlled study aims to evaluate the neuropsychological...
In the mental health research field, there is a need for effective and robust methodological approaches that are able to address complexity. In this article, we reassert the importance of mixed methods, an approach increasingly applied within mental health...
Background
Suicidal thoughts and behaviours are common in people in prison and associated with poor health outcomes, including suicide, injury and repeat self-harm.
ObjectiveTo develop and validate a model to stratify risk of repeat suicidality up to 3 months in people...
I love a good avocado toast—simple, delicious, and healthy. But until recently, I had no idea it actually contains a surprising amount of protein! Now, it’s...
Background
Mood episodes and high suicide risk of bipolar disorder (BD) are thought to derive from amygdala–ventral prefrontal cortex emotion regulation brain circuitry dysfunction and resulting emotion dysregulation, making these potential intervention targets.
ObjectiveTo assess feasibility, acceptability, and preliminary efficacy in...