Background
Research has revealed associations between microbes of the gastrointestinal tract and stress, anxiety and depression in pregnant or postpartum women. While these studies suggest a gut-brain-behaviour axis, no studies have examined microbes of the oral cavity in relation to...
Question
The optimal dose of lurasidone for bipolar depression is unclear. This study examined its dose–response relationship for efficacy, acceptability, and metabolic/endocrine profiles.
Study selection and analysisFive databases and grey literature published until 1 August 2024, were systematically reviewed. The outcomes...
Sardines in tomato sauce are a classic cupboard staple—cheap, versatile, and easy to whip up into a quick meal. Whether you enjoy them on toast or...
Background
Available empirical evidence on participant-level factors associated with dropout from psychotherapies for post-traumatic stress disorder (PTSD) is both limited and inconclusive. More comprehensive understanding of the various factors that contribute to study dropout from cognitive-behavioural therapy with a trauma...
Advancing adolescent health research necessitates deliberate design and analysis that accurately captures the rapidly evolving world in which adolescents live and the ways in which they understand and express themselves and their experiences. In this Perspective, we reflect on...
Background
In 2021, an estimated 43% of the world's population had been diagnosed with a neurological disorder. Early life stress (ELS) is now a well-established risk factor for later-life neurological disorders. However, translation to clinical practice is hindered by oversimplification,...
Background
There are no specific national guidelines in England to guide healthcare professionals in how to assess or treat young people with tic disorders. Access to evidence-based treatment, including behavioural therapy, is of limited availability.
ObjectivesThis study examined the economic impact...
Background
Self-harm is a major health issue resulting in high societal costs. Few psychological and psychosocial interventions have shown effectiveness in reducing repeat self-harm.
ObjectiveTo assess the cost-effectiveness of psychological and psychosocial interventions that have shown evidence of effectiveness in adults...
Is there anybody who doesn’t love Crocs? They’re comfy, easy to slip on, and kind of iconic, aren’t they? I’ll admit, I have a pair myself—...
Background
Basic self-disturbance (BSD), also called anomalous self-experiences (ASEs), are core phenotypic markers for schizophrenia spectrum disorders and a prepsychotic vulnerability marker considered to be temporally stable (trait-phenomenon). Studies of BSD in children and adolescents are lacking.
ObjectiveTo be clinically useful,...