Background
Hypersexuality (HS) accompanying neurological conditions remains poorly characterized despite profound psychosocial impacts.
Objective
We aimed to systematically review the literature on HS in patients with neurological disorders.
Study selection and analysis
We conducted a systematic review to identify studies that reported HS in neurological disorders. HS was defined as a condition characterized by excessive and persistent preoccupation with sexual thoughts, urges, and behaviors that cause significant distress or impairment in personal, social, or occupational functioning. Data on demographics, assessment techniques, associated elements, phenotypic manifestations, and management strategies were also extracted.
Findings
The final analysis included 79 studies on HS, encompassing 32 662 patients across 81 cohorts with neurological disorders. Parkinson's disease was the most frequently studied condition (55.6%), followed by various types of dementia (12.7%). Questionnaires were the most common assessment approach for evaluating HS, although the techniques varied substantially. Alterations in the dopaminergic pathways have emerged as contributing mechanisms based on the effects of medication cessation. However, standardized treatment protocols still need to be improved, with significant heterogeneity in documented approaches. Critical deficiencies include risks of selection bias in participant sampling, uncontrolled residual confounding factors, and lack of blinded evaluations of reported outcomes.
Conclusions and clinical implications
Despite growth in the last decade, research on HS remains limited across neurological conditions, with lingering quality and methodological standardization deficits. Key priorities include advancing assessment tools, elucidating the underlying neurobiology, and formulating management guidelines.
PROSPERO registration numberCRD42017036478.
More people are using prescribed cannabis for health issues, making it vital to know how it’s used. There are two principal methods: using prescribed cannabis oil...
Lean Greens is a super greens powder that’s really popular among gym bunnies and folks who care a lot about their health. It helps you hit...
Many people wonder if tanning can help with weight loss by burning fat and calories. It’s a common question with a straightforward answer: tanning itself does...
Citric acid: it’s almost everywhere—from the zesty tang of your morning orange juice to the fizzy satisfaction of your favourite soft drink. Found naturally in citrus...
For over ninety years, Ryvita has been a staple in British pantries, evolving from simple rye breads to a diverse range of Crackerbreads, Thins, and more....