Archive for Author: prince

Identification of circadian-sensitive brain structure and its role in cognitive impairment and dementia

Background

Circadian disruption has been suggested to induce cognitive impairment and dementia. It remains unknown which brain structures are involved in the pathology.

Objective

To investigate which specific brain structure alterations are associated with dementia and cognitive impairment induced by circadian disruption.

Methods

Circadian...

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Trends and socioeconomic inequalities in acute mental health service use in Canada, 2004–2019: a nationally representative retrospective cohort study

Background

Acute mental health service use (AMHSU), that is, hospitalisations and emergency department (ED) visits for mental health, have been rising in the Canadian province of Ontario and globally; however, national-level estimates are not available. We examine trends and socioeconomic...

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Impact of the COVID-19 pandemic on antidepressant prescribing with a focus on people with learning disability and autism: an interrupted time series analysis in England using OpenSAFELY-TPP

Background

COVID-19 restrictions led to increased reports of depressive symptoms in the general population and impacted health and social care services. We explored whether these changes affected antidepressant prescribing trends in the general population and those with learning disability or...

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