Question
Does neurodegenerative disease underlie the increased rate of dementia observed in older people with schizophrenia Several studies have reported a higher prevalence of dementia in people with schizophrenia compared with the general population. This may reflect a higher risk...
Background
Hypersexuality (HS) accompanying neurological conditions remains poorly characterized despite profound psychosocial impacts.
Objective
We aimed to systematically review the literature on HS in patients with neurological disorders.
Study selection and analysis
We conducted a systematic review to identify studies that reported HS in neurological disorders. HS was defined as a condition characterized by excessive and persistent preoccupation with sexual thoughts, urges, and behaviors that cause significant distress or impairment in personal, social, or occupational functioning. Data on demographics, assessment techniques, associated elements, phenotypic manifestations, and management strategies were also extracted.
Findings
The final analysis included 79 studies on HS, encompassing 32 662 patients across 81 cohorts with neurological disorders. Parkinson's disease was the most frequently studied condition (55.6%), followed by various types of dementia (12.7%). Questionnaires were the most common assessment approach for evaluating HS, although the techniques varied substantially. Alterations in the dopaminergic pathways have emerged as contributing mechanisms based on the effects of medication cessation. However, standardized treatment protocols still need to be improved, with significant heterogeneity in documented approaches. Critical deficiencies include risks of selection bias in participant sampling, uncontrolled residual confounding factors, and lack of blinded evaluations of reported outcomes.
Conclusions and clinical implications
Despite growth in the last decade, research on HS remains limited across neurological conditions, with lingering quality and methodological standardization deficits. Key priorities include advancing assessment tools, elucidating the underlying neurobiology, and formulating management guidelines.
PROSPERO registration numberCRD42017036478.
Background
New National Institute for Health and Care Excellence (NICE) guidance endorses the prescription of statins in larger population groups for the prevention of cardiovascular and cerebrovascular morbidity and mortality, especially in people with severe mental illness. However, the evidence...
Background
There are significant clinical, policy and societal concerns about the impact on young people (YP), from admission to psychiatric wards far from home. However, research evidence is scarce.
AimsTo investigate the impact of at-distance admissions to general adolescent units, from...
Background
Suicide prevention remains a high priority topic across government and the National Health Service (NHS). Prevention of Future Death (PFD) reports are produced by coroners to highlight concerns that should be addressed by organisations to prevent future deaths in...
Background
People with functional/dissociative seizures (FDS) are at elevated suicidality risk.
ObjectiveTo identify risk factors for suicidality in FDS or epilepsy.
MethodsRetrospective cohort study from the UK's largest tertiary mental healthcare provider, with linked national admission data from the Hospital Episode Statistics....
Background
Blurred work–non-work boundaries can have negative effects on mental health, including sleep.
ObjectivesIn a randomised control trial, we aimed to assess the effectiveness of an online recovery training programme designed to improve symptoms of insomnia in a working population exposed...
Background
Use of psychostimulants and relative drugs has increased worldwide in treatment of attention-deficit hyperactivity disorder (ADHD) in adolescents and adults. Recent studies suggest a potential association between use of psychostimulants and psychotic symptoms. The risk may not be the...
Background
Although lifestyle-based treatment approaches are recommended as important aspects of depression care, the quantitative influence of aggregated healthy lifestyles on depression recurrence and mortality remains unknown.
ObjectiveTo investigate the association between healthy lifestyle and the risks of first-time hospitalisation for...
Background
Mental health disorders (MHDs) are associated with physical health disparities, but underlying excess risk and health burden have not yet been comprehensively assessed.
ObjectiveTo assess the burden of comorbid physical health conditions (PHCs) across serious MHDs in Europe.
MethodsWe estimated the...