Assessing violence risk in first-episode psychosis: external validation, updating and net benefit of a prediction tool (OxMIV)

3 years ago

Background Violence perpetration is a key outcome to prevent for an important subgroup of individuals presenting to mental health services,…

New living evidence resource of human and non-human studies for early intervention and research prioritisation in anxiety, depression and psychosis

3 years ago

In anxiety, depression and psychosis, there has been frustratingly slow progress in developing novel therapies that make a substantial difference…

Associations between antipsychotics and the risk of incident cardiovascular diseases in individuals with schizophrenia: a nested case-control study

3 years ago

Background The association between antipsychotics and cardiovascular diseases (CVDs) remains significant yet unestablished, especially in Chinese populations. Objective To investigate…

Effectiveness of a mental health stepped-care programme for healthcare workers with psychological distress in crisis settings: a multicentre randomised controlled trial

3 years ago

Background Evidence-based mental health interventions to support healthcare workers (HCWs) in crisis settings are scarce. Objective To evaluate the capacity…

Insulin resistance, age and depressions impact on cognition in middle-aged adults from the PREVENT cohort

3 years ago

Background Alzheimer's disease (AD), type 2 diabetes mellitus (characterised by insulin resistance) and depression are significant challenges facing public health.…

Increasing the value of digital phenotyping through reducing missingness: a retrospective review and analysis of prior studies

3 years ago

Background Digital phenotyping methods present a scalable tool to realise the potential of personalised medicine. But underlying this potential is…

Crossroads of methodological choices in research synthesis: insights from two network meta-analyses on preventing relapse in schizophrenia

3 years ago

In recent years, network meta-analyses have been increasingly carried out to inform clinical guidelines and policy. This approach is under…

Digital mental health: challenges and next steps

3 years ago

Digital innovations in mental health offer great potential, but present unique challenges. Using a consensus development panel approach, an expert,…

Placebo response in trials with patients with anxiety, obsessive-compulsive and stress disorders across the lifespan: a three-level meta-analysis

3 years ago

Question Randomised controlled trials assessing treatments for anxiety, obsessive-compulsive and stress-related disorders often present high placebo response rates in placebo…

Blinding successfulness in antipsychotic trials of acute treatment for schizophrenia: a systematic review

3 years ago

Background Blinding of randomised controlled trials (RCTs) is very important for the accurate assessment of drug efficacy. Without proper blinding,…