Mental health

Basic self-disturbance in adolescents at risk of psychosis: temporal stability investigated by the experience sampling method in a mixed method study

Background Basic self-disturbance (BSD), also called anomalous self-experiences (ASEs), are core phenotypic markers for schizophrenia spectrum disorders and a prepsychotic…

1 year ago

Association between cannabis use and brain structure and function: an observational and Mendelian randomisation study

Background Cannabis use during adolescence and young adulthood has been associated with brain harm, yet despite a rapid increase in…

1 year ago

Development and validation of a prognostic model to predict relapse in adults with remitted depression in primary care: secondary analysis of pooled individual participant data from multiple studies

Background Relapse of depression is common and contributes to the overall associated morbidity and burden. We lack evidence-based tools to…

1 year ago

Association between severe childhood infections and subsequent risk of OCD is largely explained by shared familial factors

Introduction Obsessive-compulsive disorder (OCD) is only moderately heritable1 2, but surprisingly little is known about potential environmental risk factors contributing…

1 year ago

Randomised controlled trial comparing different intersession intervals of intermittent theta burst delivered to the dorsal medial prefrontal cortex

Background Intermittent theta burst stimulation (iTBS) is a form of repetitive transcranial magnetic stimulation (rTMS) that can be administered in…

2 years ago

Risk of repeat self-harm among individuals presenting to healthcare services: development and validation of a clinical risk assessment model (OxSET)

Background A self-harm episode is a major risk factor for repeat self-harm. Existing tools to assess and predict repeat self-harm…

2 years ago

Complex trauma and the unseen: who gets to be a victim?

The inclusion of complex post-traumatic stress disorder (cPTSD) in the International Classification of Diseases 11th Revision in January 2022 marks…

2 years ago

Systematic review of interventions for mental health, cognition and psychological well-being in long COVID

Aims This systematic review aims to identify and synthesise the publicly available research testing treatments for mental health, cognition and…

2 years ago

Changes in sleep patterns in people with a history of depression during the COVID-19 pandemic: a natural experiment

Background The COVID-19 pandemic, while a major stressor, increased flexibility in sleep–wake schedules. Objectives To investigate the impact of the…

2 years ago

Mediation-adjusted multivariable Mendelian randomisation study identified novel metabolites related to mental health

Background From the pathway perspective, metabolites have the potential to improve knowledge about the aetiology of psychiatric diseases. Previous studies…

2 years ago