Mental health

Predictors of study dropout in cognitive-behavioural therapy with a trauma focus for post-traumatic stress disorder in adults: An individual participant data meta-analysis

Background Available empirical evidence on participant-level factors associated with dropout from psychotherapies for post-traumatic stress disorder (PTSD) is both limited…

3 months ago

Trans and gender diverse identities in adolescent health research: making the most of imperfect data

Advancing adolescent health research necessitates deliberate design and analysis that accurately captures the rapidly evolving world in which adolescents live…

3 months ago

Healthcare utilisation and costs associated with poor access to diagnosis and treatment for children and young people with tic disorders

Background There are no specific national guidelines in England to guide healthcare professionals in how to assess or treat young…

3 months ago

Integrating early life stress in neurological disease: advancing preventive neurology

Background In 2021, an estimated 43% of the world's population had been diagnosed with a neurological disorder. Early life stress…

3 months ago

Cost-effectiveness of psychological and psychosocial interventions for adults, children and young people who have self-harmed

Background Self-harm is a major health issue resulting in high societal costs. Few psychological and psychosocial interventions have shown effectiveness…

3 months ago

Basic self-disturbance in adolescents at risk of psychosis: temporal stability investigated by the experience sampling method in a mixed method study

Background Basic self-disturbance (BSD), also called anomalous self-experiences (ASEs), are core phenotypic markers for schizophrenia spectrum disorders and a prepsychotic…

3 months ago

Association between cannabis use and brain structure and function: an observational and Mendelian randomisation study

Background Cannabis use during adolescence and young adulthood has been associated with brain harm, yet despite a rapid increase in…

3 months ago

Development and validation of a prognostic model to predict relapse in adults with remitted depression in primary care: secondary analysis of pooled individual participant data from multiple studies

Background Relapse of depression is common and contributes to the overall associated morbidity and burden. We lack evidence-based tools to…

3 months ago

Association between severe childhood infections and subsequent risk of OCD is largely explained by shared familial factors

Introduction Obsessive-compulsive disorder (OCD) is only moderately heritable1 2, but surprisingly little is known about potential environmental risk factors contributing…

3 months ago

Randomised controlled trial comparing different intersession intervals of intermittent theta burst delivered to the dorsal medial prefrontal cortex

Background Intermittent theta burst stimulation (iTBS) is a form of repetitive transcranial magnetic stimulation (rTMS) that can be administered in…

3 months ago