Background
Available empirical evidence on participant-level factors associated with dropout from psychotherapies for post-traumatic stress disorder (PTSD) is both limited and inconclusive. More comprehensive understanding of the various factors that contribute to study dropout from cognitive-behavioural therapy with a trauma...
Advancing adolescent health research necessitates deliberate design and analysis that accurately captures the rapidly evolving world in which adolescents live and the ways in which they understand and express themselves and their experiences. In this Perspective, we reflect on...
Background
There are no specific national guidelines in England to guide healthcare professionals in how to assess or treat young people with tic disorders. Access to evidence-based treatment, including behavioural therapy, is of limited availability.
ObjectivesThis study examined the economic impact...
Background
In 2021, an estimated 43% of the world's population had been diagnosed with a neurological disorder. Early life stress (ELS) is now a well-established risk factor for later-life neurological disorders. However, translation to clinical practice is hindered by oversimplification,...
Background
Self-harm is a major health issue resulting in high societal costs. Few psychological and psychosocial interventions have shown effectiveness in reducing repeat self-harm.
ObjectiveTo assess the cost-effectiveness of psychological and psychosocial interventions that have shown evidence of effectiveness in adults...
Background
Basic self-disturbance (BSD), also called anomalous self-experiences (ASEs), are core phenotypic markers for schizophrenia spectrum disorders and a prepsychotic vulnerability marker considered to be temporally stable (trait-phenomenon). Studies of BSD in children and adolescents are lacking.
ObjectiveTo be clinically useful,...
Background
Cannabis use during adolescence and young adulthood has been associated with brain harm, yet despite a rapid increase in cannabis use among older adults in the past decade, the impact on brain health in this population remains understudied.
ObjectiveTo explore...
Background
Relapse of depression is common and contributes to the overall associated morbidity and burden. We lack evidence-based tools to estimate an individual's risk of relapse after treatment in primary care, which may help us more effectively target relapse prevention.
ObjectiveThe...
Introduction
Obsessive-compulsive disorder (OCD) is only moderately heritable1 2, but surprisingly little is known about potential environmental risk factors contributing to its aetiology.3 4
A potential environmental risk factor that has gathered considerable attention is infections, hypothesised to be...
Background
Intermittent theta burst stimulation (iTBS) is a form of repetitive transcranial magnetic stimulation (rTMS) that can be administered in a fraction of the time of standard rTMS. Applying multiple daily iTBS sessions (ie, accelerated iTBS) may enable patients to...