Archive for Category: Mental health

Effectiveness of pharmacological and non-pharmacological interventions for treatment-resistant depression in older patients: a systematic review and meta-analysis

Background

Depression in older adults is often undertreated. A 2011 systematic review of treatments for treatment-resistant depression (TRD) in older adults identified one placebo-controlled randomised controlled trial (RCT). We aimed to update this review, synthesising evidence for the effectiveness of...

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Lack of neuropsychological effects following short-term subcallosal cingulate gyrus deep brain stimulation in treatment-resistant depression: a randomised crossover study

Background

The subcallosal cingulate gyrus (SCG) is integral to cognitive function and mood regulation. Open-label SCG deep brain stimulation (DBS) studies demonstrate improvement or stabilisation of cognitive function in treatment-resistant depression (TRD).

Objective

This randomised controlled study aims to evaluate the neuropsychological...

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