Background
Depression is a major health issue in adolescence and young adulthood, emphasising the need for early risk identification. Patients with major depressive disorder (MDD) often show disturbed daily rest-activity patterns, but such changes are often confounded by medication intake,...
Background
Differentiating major depressive disorder (MDD) from bipolar disorder (BD) remains a significant clinical challenge, as both disorders exhibit overlapping symptoms but require distinct treatment approaches. Advances in voxel-based morphometry and surface-based morphometry have facilitated the identification of structural brain...
Background
Chronic inflammation is associated with psychiatric disorders. If inflammation is linked mechanistically to mental health, people living with chronic inflammatory conditions may experience mental health issues at higher rates than others.
ObjectiveTo test this hypothesis, we analysed data from 1...
Background
Approximately 30% of women experience intimate partner violence (IPV) in their lifetime, often with traumatic brain injury (TBI) exposure. Nevertheless, there has been limited research exploring lifelong brain health outcomes following IPV with TBI. To address this, we investigated...
Background
The mental health of children and adolescents has declined in recent years. Self-harm is frequently an expression of this psychological distress.
ObjectivesTo examine trends in self-harm incidence among 10–24-year olds between January 2019–December 2023.
MethodsWe conducted time-series analyses of all incident...
Well-synchronised circadian rhythms are fundamental for human health and particularly mental health, but patterns of modern living—including, for example, shift work and excess light at night—can cause desynchronisation of rhythms and result in a wide range of adverse mental...
Background
The onset of a severe physical illness of a child has been associated with earnings and employment losses among parents, but less is known in the context of children's mental disorders.
ObjectivesWe estimated parental income and employment trajectories associated with...
Background
Evidence regarding early interventions based on the Naturalistic Developmental Behavioral Interventions framework, such as the Early Start Denver Model (ESDM), suggests efficacy for autistic children. However, the effectiveness of ESDM across diverse cultural contexts remains under-researched.
ObjectiveTo assess the effectiveness...
Background
Routine outcome data in secondary mental health services have significant potential for service planning, evaluation and research. Expanding the collection and use of these data is an ongoing priority in the National Health Service (NHS), but inconsistent use threatens...
Background
Understanding the relationship between mental and physical health conditions is crucial for developing comprehensive healthcare strategies. The putative existence of a general disease factor (d-factor) that underlies the vulnerability to both physical and mental conditions could have important implications...