Background
Genetic and environmental factors contribute to the pathogenesis of schizophrenia (SZ) and bipolar disorder (BD). Among genetic risk groups stratified by combinations of Polygenic Risk Score (PRS) deciles for SZ, BD and SZ versus BD, genetic SZ risk groups...
Background
Internet-based cognitive–behavioural therapy (iCBT) is effective for subthreshold depression. However, iCBT has problems with adherence, especially when unaccompanied by human guidance. Knowledge on how to enhance adherence to iCBT without human involvement can contribute to improving the effectiveness of...
Background
Approximately 30% of patients experience substantial improvement in depression after 2 months without treatment, and 45% with antidepressants. The smallest worthwhile difference (SWD) refers to an intervention's smallest beneficial effect over a comparison patients deem worthwhile given treatment burdens...
BMJ Mental Health is delighted to announce a new section called Experience, Ethics, Equity that seeks submissions of primary research, systematic reviews, and perspectives and commentaries. We set out the case for such a section, and then give some...
Background
The increasing prevalence and acuity of mental disorders among children and adolescents have placed pressure on services, including inpatient care, and resulted in young people being admitted at-distance or to adult wards. Little empirical research has investigated such admissions.
ObjectiveTo...
Background
Higher social support protects people from developing mental disorders. Limited evidence is available on the mechanism through which social support plays this protective role.
ObjectiveTo investigate the stress-buffering process of social support on depressive symptoms using a novel longitudinal dynamic...
Background
Despite the evidence supporting the relationship between socioeconomic status (SES) and severe mental disorders (SMD), the directionality of the associations between income or education and mental disorders is still poorly understood.
ObjectiveTo investigate the potential bidirectional causal relationships between genetic...
Background
The correlates and consequences of stigma surrounding alcohol use are complex. Alcohol use disorder (AUD) is typically accompanied by self-stigma, due to numerous factors, such as shame, guilt and negative stereotypes. Few studies have empirically examined the possible association...
Background
Psychiatric disorders have serious harm to individuals' lives with high disease burden. Observational studies reported inconsistent associations between periodontitis and some psychiatric disorders, and the causal correlations between them remain unknown.
ObjectiveThis study aims to explore the causal associations between...
Background
More knowledge on the cost-effectiveness of various depression treatment programmes can promote efficient treatment allocation and improve the quality of depression care.
ObjectiveThis study aims to compare the real-world cost-effectiveness of an algorithm-guided programme focused on remission to a predefined...