Background Increasing data suggest emergent affective symptoms during the COVID-19 pandemic. Objectives To study the impact of the COVID-19 pandemic…
Background All-cause and suicide mortalities of gender-referred adolescents compared with matched controls have not been studied, and particularly the role…
Question Depression is highly prevalent and associated with numerous adverse consequences for both individuals and society. Due to low uptake…
Question We examined the effect of study characteristics, risk of bias and publication bias on the efficacy of pharmacotherapy in…
Background The relationship between adverse childhood experiences (ACEs) and depression risk has been well documented. However, it remains unclear whether…
Background Patients diagnosed with psychosis often spend less time than others engaged in exercise and more time sitting down, which…
Question Children and young people experience delays in assessment and/or treatment within mental health services. The objective of this systematic…
Background Post-traumatic stress symptoms (PTSS) are frequently observed in those who have experienced trauma events like the COVID-19 outbreak. The…
Question Tricyclic antidepressants are used to treat depression worldwide, but the adverse effects have not been systematically assessed. Our objective…
Background Melatonin is commonly used to treat sleep disturbance in children and adolescents, although uncertainties about its optimal use remain.…