Mental health

Genome-wide DNA methylation risk scores for schizophrenia derived from blood and brain tissues further explain the genetic risk in patients stratified by polygenic risk scores for schizophrenia and bipolar disorder

Background Genetic and environmental factors contribute to the pathogenesis of schizophrenia (SZ) and bipolar disorder (BD). Among genetic risk groups…

2 years ago

A chatbot to improve adherence to internet-based cognitive-behavioural therapy among workers with subthreshold depression: a randomised controlled trial

Background Internet-based cognitive–behavioural therapy (iCBT) is effective for subthreshold depression. However, iCBT has problems with adherence, especially when unaccompanied by…

2 years ago

Estimating the smallest worthwhile difference of antidepressants: a cross-sectional survey

Background Approximately 30% of patients experience substantial improvement in depression after 2 months without treatment, and 45% with antidepressants. The…

2 years ago

Understanding and responding to the drivers of inequalities in mental health

BMJ Mental Health is delighted to announce a new section called Experience, Ethics, Equity that seeks submissions of primary research,…

2 years ago

‘Far Away from Home: adolescent inpatient admissions far from home, out of area or to adult wards: a national surveillance study

Background The increasing prevalence and acuity of mental disorders among children and adolescents have placed pressure on services, including inpatient…

2 years ago

Understanding the protective effect of social support on depression symptomatology from a longitudinal network perspective

Background Higher social support protects people from developing mental disorders. Limited evidence is available on the mechanism through which social…

2 years ago

Socioeconomic status and severe mental disorders: a bidirectional multivariable Mendelian randomisation study

Background Despite the evidence supporting the relationship between socioeconomic status (SES) and severe mental disorders (SMD), the directionality of the…

2 years ago

Relationship between self-stigma about alcohol dependence and severity of alcohol drinking and craving

Background The correlates and consequences of stigma surrounding alcohol use are complex. Alcohol use disorder (AUD) is typically accompanied by…

2 years ago

Genetically predicted causal associations between periodontitis and psychiatric disorders

Background Psychiatric disorders have serious harm to individuals' lives with high disease burden. Observational studies reported inconsistent associations between periodontitis…

2 years ago

Comparative analysis of algorithm-guided treatment and predefined duration treatment programmes for depression: exploring cost-effectiveness using routine care data

Background More knowledge on the cost-effectiveness of various depression treatment programmes can promote efficient treatment allocation and improve the quality…

2 years ago